Xagena.net - Update in Medicine


The final results from an international clinical trial involving nearly 2,000 patients with Crohn's disease support the use of a new management strategy referred to as accelerated step-care as a best practice for the care of active Crohn's disease.
The REACT ( Randomized Evaluation of an Algorithm for Crohn's Treatment ) study provides valuable new insights for community gastroenterologists which should benefit patients.

Crohn's disease is a chronic, potentially debilitating, condition of the gastrointestinal tract which can cause abdominal pain, diarrhea, vomiting, and weight loss among other symptoms.
Well over five million people globally are affected by Crohn's disease and ulcerative colitis.

The medical management of Crohn's disease has undergone important changes over the past two decades with the introduction of TNF antagonists such as Adalimumab ( Humira ) and Infliximab ( Remicade ).
The current treatment approach features sequential and incremental treatment intensification based on symptoms. In contrast, an accelerated step-care approach involves the early introduction of combined immunosuppression in high risk patients, which has been shown to induce and maintain remission, reduce the use of corticosteroids, and heal intestinal ulceration in those who fail conventional treatment.

Subsequent research, performed in both Crohn's disease and rheumatoid arthritis, indicated that TNF antagonists work best when: 1) used in combination with antimetabolites ( e.g., Azathioprine, Methotrexate ) and 2) introduced early in the course of the disease.
Controlled studies such as CHARM ( Crohn's Trial of the Fully Human Antibody Adalimumab for Remission Maintenance ) have also demonstrated that TNF antagonist-based regimens can reduce the rate of surgery and hospitalization in comparison to conventional therapy.

In the REACT trial, 39 community gastroenterology practices in Canada or Belgium were randomly assigned to a conventional management approach or to an accelerated step-care algorithm that featured early use of Adalimumab and antimetabolite therapy.
Within practices, up to 60 consecutive patients were entered and evaluated for 24 months to determine whether the implementation of an accelerated step-care approach would improve the management of Crohn's disease in comparison to conventional management methods.

Final results from the REACT clinical trial have showen the proportion of patients in remission at 12 months was marginally greater in the group assigned to accelerated step-care. However, significant and clinically important reduction in rates for hospitalization, complications and surgeries were observed in practices assigned to early combined immunosuppression up to 24 months.

The study reached several important conclusions: a) early introduction of combined therapy in the community may be both feasible and safe; b) use of this paradigm may be more effective than conventional management for the prevention of disease–related complications, surgeries and hospitalizations; c) reliance on symptoms exclusively to guide therapy may be a sub-optimal management strategy. ( Xagena )

Source: University of Western Ontario, 2014

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